Digestive Issues: Bloating, gas, and diarrhea can occur due to difficulty digesting large amounts of protein.

Dehydration: Increased protein intake may raise the body's water needs, potentially leading to dehydration if not adequately hydrated.

Kidney Strain: Excessive protein can strain kidneys by increasing nitrogen load, especially risky for those with pre-existing kidney issues.

Nutrient Imbalance: Over-reliance on protein supplements can lead to deficiencies in other essential nutrients like fiber, vitamins, and minerals.

Weight Gain: Without compensating for extra protein calories, it can contribute to weight gain.

Liver Stress: High protein intake may stress the liver as it metabolizes excess protein.

Bone Health: There's concern that very high protein intake might negatively affect calcium balance and bone health.